Identification of risk factors can aid in improving the treatment and monitoring of pwMS and COVID-19.Īnti-CD20 therapy COVID-19 Comorbidity Disease-modifying therapy Multiple sclerosis Regression analyses, odds ratio.Ĭopyright © 2022 The Authors. Age, sex, smoking history, and duration of MS did not show a significant association with severity or adverse COVID-19 disease outcome. Comorbidities were associated with a higher risk of non-recovery from COVID-19 in both univariate and multivariate analyses. Univariate regression analysis showed high EDSS scores, progressive MS disease, and use of anti-CD20 therapy such as rituximab as risk factors for moderate to severe COVID-19 requiring hospitalization. The median EDSS score reported in the study was low (1.0). A majority (126 ) of patients had mild COVID-19 illness and 122 (91.0%) made a full recovery, while 1 (0.7%) patient died. A total of 134 MS patients with COVID-19 (prevalence rate of 3.7%) having a median age of 35.5 years were analyzed in the study. The association of patient demographics, MS disease characteristics, and use of disease-modifying therapies with outcomes of COVID-19 illness were evaluated using odds ratio. The study was conducted at multiple clinics in Oman, Kuwait, and the United Arab Emirates (UAE) from March 2020 to February 2021. Electronic address: cross-sectional hospital records-based study was conducted to evaluate the prevalence, severity, outcomes, and identify demographic and clinical risk factors of coronavirus disease (COVID-19) in patients with MS. Electronic address: 8 Neurology, Ibn Sina Hospital, Kuwait city, Kuwait Neurolopsychiatry, Minia University, Minia, Egypt. 7 Neurology Unit, Department of Medicine Jahra Hospital, Jahra City, Kuwait.Electronic address: 6 Neurology Department, Rashid Hospital Dubai, UAE. Electronic address: 5 Neurology Unit, College of Medicine and Health Sciences, Sultan Qaboos University and Sultan Qaboos University Hospital, Muscat, Oman. Electronic address: 4 Neurology Unit, College of Medicine and Health Sciences, Sultan Qaboos University and Sultan Qaboos University Hospital, Muscat, Oman. Electronic address: 3 Neurology, Ibn Sina Hospital, Kuwait city, Kuwait Faculty of Medicine, Kuwait University, Kuwait. Electronic address: 2 Neurology Department, Rashid Hospital Dubai, UAE Dubai Medical College, Dubai, UAE.
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